HORDB

ID: hor005786
Uniprot ID: P11006
Protein name: Magainin-2
Gene name: magainins
Organism: Xenopus laevis (African clawed frog)
Family: Gastrin/cholecystokinin family, Magainin subfamily
Source: animal
Expression: Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin.
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: GO:0002376 immune system process; GO:0006952 defense response; GO:0031640 killing of cells of another organism; GO:0042742 defense response to bacterium; GO:0045087 innate immune response; GO:0050688 regulation of defense response to virus; GO:0050832 defense response to fungus
GO CC: GO:0005576 extracellular region

Sequence: GIGKFLHSAKKFGKAFVGEIMNS
Length: 23(83-105)
Propeptide: MFKGLFICSLIAVICANALPQPEASADEDMDEREVRGIGKFLHSAGKFGKAFVGEIMKSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDFDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAF
Signal peptide: MFKGLFICSLIAVICANA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Rapidly inactivates channel catfish herpesvirus (ED(50)=48 uM) over a wide temperature range (PubMed:15193922). Magainins are me
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005786_AF2.pdb

hor005786_ESM.pdb

Mass:	285952	Formula:	C114H180N30O29S
Absent amino acids:	CDPQRTWY	Common amino acids:	GK
pI:	10.8	Basic residues:	5
Polar residues:	7	Hydrophobic residues:	9
Hydrophobicity:	8.26	Boman Index:	-964
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	72.17
Instability Index:	-49.57	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2833514
Title: The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide.
PubMed ID: 3299384
Title: Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequenc
PubMed ID: 1717472
Title:
PubMed ID: 15193922
Title:
PubMed ID: 8298457
Title: